Skin corrosion testing

OECD TG 431

For this test, 3D reconstructed human skin models are incubated with the test material for 3 minutes and for one hour. After exposure, models are rinsed and viability is assessed using the MTT test (colorimetric assay). If remaining viability is > 50% (3 min exposure) and > 15% (1h exposure) the test material is classified “non-corrosive”.

Prediction Model

Mean tissue viability (expressed as % of negative control) Prediction
3 min < 50% corrosive
3 min > 50% and 1 hour < 15% corrosive
3 min > 50% and 1 hour > 15% non-corrosive

The test is not designed to distinguish between sub-categories of corrosivity. However, 70% of the chemicals that are already corrosive in vivo after 3 minutes of exposure are also corrosive in the skin model after 3 minutes of exposure. The test is not designed to predict skin irritation potential.

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